Bicalutamide/Casodex is a synthetic, non-steroidal, pure antiandrogen used in the treatment of prostate cancer, hirsutism, and other androgen-dependent conditions in Kenya.
SKU: EP1253 Category:


Bicalutamide is a nonsteroidal anti-androgen with actions and uses similar to those of flutamide. It is used by mouth in the treatment of prostatic cancer in Kenya. When used with a gonadorelin analogue in the palliative treatment of advanced prostatic cancer the usual dose is 50 mg daily. In Kenya treatment is started at least 3 days before commencing the gonadorelin analogue to suppress any flare reaction, but in the USA treatment is started at the same time. A similar dose is used with surgical castration, starting on the same day as surgery.

Bicalutamide in a dose of 150 mg daily may be given as monotherapy or adjuvant therapy to surgery or radiotherapy in men with locally advanced disease. It has been used as monotherapy in localised disease, but there is some evidence to suggest that in men without high risk of disease progression, who would otherwise be managed with watchful waiting, the immediate use of bicalutamide may increase the risk of death.

Interactions of other drugs with Casodex

Casodex inhibits various cytochrome P450 isoenzymes, particularly CYP3A4, in vitro, and the manufacturer recommends that terfenadine, astemizole, and cisapride should not be given with bicalutamide, and that other drugs with a narrow therapeutic index that are metabolised by cytochrome P450 isoenzymes should be used with caution.

Common adverse effects and side effects of Casodex/Bucalutamide

Cardiovascular effects including angina, arrhythmias, heart failure, and ECG changes have been reported rarely. Interstitial pneumonitis and pulmonary fibrosis have also been reported rarely.

Single-ingredient Preparations of Bucalutamide

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed. Arg.: Androxinon; Bicaprost; Bidrostat; Bosconar; Casodex; Gepeprostin; Imda; Liberprost; Raffolutil; Austral.: Cosudex; Austria: Casodex; Belg.: Casodex; Braz.: Casodex; Canad.: Casodex; Chile: Casodex; Lutamidal; Denm.: Casodex; Fin.: Casodex; Fr.: Casodex; Ger.: Casodex; Gr.: Casodex; Hong Kong: Casodex; Hung.: Casodex; Irl.: Casodex; Israel: Casodex; Ital.: Casodex; Malaysia: Casodex; Mex.: Casodex; Neth.: Casodex; Norw.: Casodex; NZ: Cosudex; Port.: Casodex; S.Afr.: Casodex; Singapore: Casodex; Spain: Casodex; Swed.: Casodex; Switz.: Casodex; Thai.: Casodex; UK: Casodex; USA: Casodex;


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