Cefixime is available as the trihydrate and doses are expressed in terms of anhydrous cefixime; 1.12 g of cefixime trihydrate is equivalent to about 1 g of anhydrous cefixime. It is given by mouth in adult doses of 200 to 400 mg daily as a single dose or in two divided doses. Children over 6 months and under 50 kg may be given 8 mg/kg daily as an oral suspension, again as a single dose or in two divided doses. For uncomplicated gonorrhoea, a single oral dose of 400 mg is given.
Care should be exercised in patients receiving anticoagulants and cefixime due to the possibility that ceflorex may increase prothrombin times
Adverse Effects and Precautions
The most frequently reported adverse effects of cefixime are gastrointestinal disturbances, especially diarrhoea. Cefixime should be stopped if diarrhoea is severe.
Although cefixime does not have the N-methylthiotetrazole side-chain usually associated with hypoprothrombinaemia increases in prothrombin times have occurred in a few patients.