Ceflorex is a brand name of Cefixime, generally classified as a third-generation cephalosporin antibacterial and is given by mouth in the treatment of susceptible infections including gonorrhoea, otitis media, pharyngitis, lower respiratory-tract infections such as bronchitis, and urinary-tract infections. For details of these infections and their treatment, see under Choice of Antibacterial

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Cefixime is available as the trihydrate and doses are expressed in terms of anhydrous cefixime; 1.12 g of cefixime trihydrate is equivalent to about 1 g of anhydrous cefixime. It is given by mouth in adult doses of 200 to 400 mg daily as a single dose or in two divided doses. Children over 6 months and under 50 kg may be given 8 mg/kg daily as an oral suspension, again as a single dose or in two divided doses. For uncomplicated gonorrhoea, a single oral dose of 400 mg is given.


Care should be exercised in patients receiving anticoagulants and cefixime due to the possibility that ceflorex may increase prothrombin times

Adverse Effects and Precautions

The most frequently reported adverse effects of cefixime are gastrointestinal disturbances, especially diarrhoea. Cefixime should be stopped if diarrhoea is severe.

Although cefixime does not have the N-methylthiotetrazole side-chain usually associated with hypoprothrombinaemia increases in prothrombin times have occurred in a few patients.


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