Description
Tamsulosin is an alpha1-adrenoceptor blocker; it is reported to be more selective for the alpha1A-adrenoceptor subtype, which accounts for approximately 70% of the ?1 adrenoceptors in the prostate.. It is used in benign prostatic hyperplasia to relieve symptoms of urinary obstruction.
Tamsulosin is given by mouth as the hydrochloride. In benign prostatic hyperplasia it is administered in a modified-release formulation, in a dose of 400 micrograms once daily, after food at the same time each day. The manufacturer states that the dose may be increased after 2 to 4 weeks, if necessary, to 800 micrograms once daily when the symptoms are not relieved after that duration.
Adverse Effects of Tamsulosin
Because tamsulosin is selective for ?1 receptors in the prostate the vasodilator effects may be less frequent. Tamsulosin may cause ejaculation abnormalities. It should be avoided in severe hepatic impairment.
Single-ingredient Preparations
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
Arg.: Aclosan; Omnic; Reduprost; Secotex; Austral.: Flomax; Austria: Alna; Omix¤; Belg.: Omic; Braz.: Omnic; Secotex; Canad.: Flomax; Chile: Omnic; Prostall; Secotex; Denm.: Omnic; Fin.: Expros; Omnic; Fr.: Josir; Omix; Ger.: Alna; Omnic¤; Gr.: Omnic; Pradif; Hung.: Omnic; Irl.: Omnic; Israel: Omnic; Ital.: Omnic; Pradif; Jpn: Harnal; Mex.: Secotex; Neth.: Omnic; Norw.: Omnic; NZ: Flomax; Port.: Omnic; Pradif; S.Afr.: Flomax; Spain: Omnic; Urolosin; Switz.: Pradif; Thai.: Harnal; UK: Flomax; USA: Flomax;
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