Flucloxacillin is an isoxazolyl penicillin available in Kenya as FLOXAPEN. It is used primarily for treating bacterial infections associated with staphylococci resistant to benzylpenicillin. These include endocarditis, bone and joint infections, pneumonia, toxic shock syndrome, and skin infections (including soft-tissue infections)

Hepatitis and cholestatic jaundice have occasionally been reported while using FLOXAPEN in Kenya; older patients and those receiving more than 2 weeks treatment of Flucloxacillin are at greater risk. Fatalities have occurred, especially in patients with serious underlying hepatic disease. Rare reports of erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome associated with flucloxacillin have been made. Agranulocytosis and neutropenia have been associated rarely with isoxazolyl penicillins such as flucloxacillin. Phlebitis has followed intravenous infusion.

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