Terazosin/HYTRIN in Kenya is an alpha1-adrenoceptor blocker with actions similar to those of prazosin, but a longer duration of action. It is used in the management of hypertension and in benign prostatic hyperplasia to relieve symptoms of urinary obstruction. For hypertension the usual maintenance dose of HYTRIN is 2 to 10 mg once daily and the usual maximum dose is 20 mg daily in a single dose or two divided doses. For benign prostatic hyperplasia the usual maintenance dose is 5 to 10 mg once daily, but lower doses of 2mg have also be used.

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COMMON Adverse Effects

Hytrin can cause orthostatic hypotension which may be severe and produce syncope after the initial dose; it may be preceded by tachycardia. This reaction can be avoided by starting treatment with a low dose, preferably at night. The hypotensive effects may be exaggerated by exercise, heat, or alcohol ingestion.

The more common adverse effects include dizziness, drowsiness, headache, lack of energy, nausea, and palpitations, and may diminish with continued HYTRIN therapy in Kenya or with a reduction in dosage. Other adverse effects include oedema, chest pain, dyspnoea, constipation, diarrhoea, vomiting, depression and nervousness, sleep disturbances, vertigo, hallucinations, paraesthesia, nasal congestion, epistaxis, dry mouth, urinary frequency and incontinence, reddened sclera, blurred vision, tinnitus, abnormal liver enzyme values, pancreatitis, arthralgia, alopecia, lichen planus, skin rashes, pruritus, and diaphoresis. Impotence and priapism have also been reported.


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