Uses and Administration of Pantoprazole in Kenya
Pantoprazole/Panpure/Pantor is a proton pump inhibitor with actions and uses similar to those of omeprazole. Once-daily doses should be taken in the morning.
In the treatment of gastro-oesophageal reflux disease, the usual dose by mouth is 20 to 40 mg once daily for 4 weeks, increased to 8 weeks if necessary; in Kenya, up to 16 weeks’ therapy is permitted for healing of erosive oesophagitis. For maintenance therapy, treatment can be continued with 20 to 40 mg daily.
The usual dose for the treatment of peptic ulcer disease is 40 mg once daily. Treatment is usually given for 2 to 4 weeks for duodenal ulceration, or 4 to 8 weeks for benign gastric ulceration. For the eradication of Helicobacter pylori in Kenyan patients pantoprazole may be combined with two antibacterials in a 1-week triple therapy regimen. Effective regimens include pantoprazole 40 mg twice daily combined with clarithromycin 500 mg twice daily and either amoxicillin 1g twice daily or metronidazole 400 mg twice daily.
Patients who require prophylaxis for NSAID-associated ulceration may take 20 mg daily.
In the treatment of pathological hypersecretory states such as the Zollinger-Ellison syndrome, the initial dose is 80 mg daily, adjusted as required. Doses of up to 240 mg daily have been tried with no significant side effect witnessed. Daily doses greater than 80 mg should be given in 2 divided doses, as no beneficial results have been recorded for using more than 80mg doses as single doses.
Pantoprazole/Pantoloc may also be given intravenously, as the sodium salt, in recommended doses of 40 mg daily given over 2 to 15 minutes. A dose of 80 mg daily may be used for Zollinger-Ellison syndrome or up to 240 mg daily in divided doses if rapid control is required.
Dosage of pantoprazole/Pantocid may need to be reduced in severe hepatic impairment, or doses given only on alternate days. A maximum dose of 20 mg daily, or 40 mg on alternate days, has been suggested.
What are the Adverse Effects and Side Effects of Pantoprazole/Pantel
Adverse effects reported most frequently with Pantoprazole and other proton pump inhibitors have been headache, diarrhoea, and skin rashes; they have sometimes been severe enough to require discontinuation of treatment. Other effects include pruritus, dizziness, fatigue, constipation, nausea and vomiting, flatulence, abdominal pain, arthralgia and myalgia, urticaria, and dry mouth. Isolated cases of photosensitivity, bullous eruption, erythema multiforme, angioedema, and anaphylaxis have been reported. Effects on the CNS include occasional insomnia, somnolence, and vertigo; reversible confusional states, agitation, depression, and hallucinations have occurred in severely ill patients. Raised liver enzymes, and isolated cases of hepatitis, jaundice, and hepatic encephalopathy, have been reported. Other adverse effects reported rarely or in isolated cases include paraesthesia, blurred vision, alopecia, stomatitis, sweating, taste disturbances, peripheral oedema, malaise, hyponatraemia, blood disorders (including agranulocytosis, leucopenia, and thrombocytopenia), and interstitial nephritis.
Proton pump inhibitors may increase the risk of gastrointestinal infections because of their acid suppressive effects.
What’s the price of Pantoprazole/Pantel in Kenya, Nairobi?
Depending on the brand, the cheapest Pantoprazole sales at Ksh. 10. Pantoprazole can be bought online in Kenya through ePharmacy Kenya’s Online drugstore portal without a prescription.