TRITACE 5MG (RAMIPRIL 5MG ) – 30 CAPSULES are used in the management of Hypertension/High Blood Pressure in Kenya. This is a condition characterized by a raise in blood pressure to levels of above 140/90mmHG. This product should not be used in pregnancy, unless with proper guidance from a qualified physician. You can procure it in Kenya online in using ePharmacy Kenya’s Online Drugstore portal.

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Uses and Administration of Ramipril in Kenya

Ramipril is an Angiotensin-Converting Enzyme inhibitor. It is used in the treatment of hypertension, heart failure, and following myocardial infarction to improve survival in patients with clinical evidence of heart failure. It is also used to reduce the risk of cardiovascular events in patients with certain risk factors.

The haemodynamic effects are seen within 1 to 2 hours of a single oral dose and the maximum effect occurs after about 3 to 6 hours, although the full effect may not develop for several weeks during chronic dosing. The haemodynamic effect is maintained for at least 24 hours, allowing once-daily dosing.

In the treatment of hypertension an initial dose of 1.25 mg once daily is given by mouth. Since there may be a precipitous fall in blood pressure when starting therapy with an Ramipril, the first dose should preferably be given at bedtime. Patients in Kenya receiving diuretics should, if possible, have the diuretic discontinued 2 to 3 days before starting ramipril, and resumed later if necessary. The usual maintenance dose is 2.5 to 5 mg daily as a single dose, although up to 10 mg daily may be required. In the USA an initial dose of 2.5 mg once daily in hypertensive patients not receiving a diuretic and a maintenance dose of 2.5 to 20 mg daily, as a single dose or in two divided doses, have been suggested.

In the management of heart failure in Kenya, severe first-dose hypotension on introduction of an Ramipril is common in patients on loop diuretics, but their temporary withdrawal may cause rebound pulmonary oedema. Thus treatment should be initiated with a low dose under close medical supervision; high doses of diuretics should be reduced before starting ramipril. Ramipril is given in an initial dose of 1.25 mg once daily. The usual maximum dose is 10 mg daily; doses of 2.5 mg or more daily may be taken in 1 or 2 divided doses.

Following myocardial infarction, treatment with ramipril may be started in hospital 3 to 10 days after the infarction at a usual initial dose of 2.5 mg twice daily, increased after two days to 5 mg twice daily. The usual maintenance dose is 2.5 to 5 mg twice daily.

For the prophylaxis of cardiovascular events in patients considered to be at high risk, ramipril is given in an initial dose of 2.5 mg once daily. The dose should be increased, if tolerated, to 5 mg once daily after 1 week, then to the usual maintenance dose of 10 mg once daily after a further 3 weeks. In patients with hypertension or recent myocardial infarction it may also be given in divided doses.

A reduction in dosage of ramipril may be necessary in patients with impaired renal function

Adverse Effects, Treatment, and Precautions of Ramipril

The most common adverse effects are due to the vascular effects of ACE inhibitors and include hypotension, dizziness, fatigue, headache, and nausea and other gastrointestinal disturbances. Otherwise, if dose is given accordingly no fatal adverse effects should be expected.


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