REGUCOLINE 750MG | CITICOLINE SOMAZINA GENERIC – 10 TABS

KSh2,410.00

Citicoline/Regucoline is a brain chemical that occurs naturally in the body. As a medicine, it is taken by mouth as a supplement tablet or sachet or given by IV or as a shot.

Refucoline/Citicoline is used for Alzheimer’s disease and other types of dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson’s disease, attention deficit-hyperactive disorder (ADHD), and glaucoma.

Citicoline was originally developed in Japan for stroke. It was later introduced as a prescription drug in many countries. In Kenya it is now frequently prescribed for thinking problems related to circulation problems in the brain. In the US, citicoline is marketed as a dietary supplement.

How does it work?

Citicoline seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured

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Description

Medical uses

Citicoline/Regucoline is available as a supplement online in Kenya and in stores offline. When taken as a supplement citicoline is hydrolyzed into choline and cytidine in the intestine. Once it crosses the blood‚Äìbrain barrier it’s converted into citicoline by the rate-limiting enzyme in phosphatidylcholine synthesis, CTP-phosphocholine cytidylyltransferase.

Dosage

The following doses have been studied in scientific research:

BY MOUTH:

  • For decline in thinking skills due to age: 1000-2000 mg of citicoline per day.
  • For ongoing disease of the blood vessels that serve the brain (chronic cerebrovascular disease): 600 mg of citicoline per day.
  • For immediate treatment of stroke due to a clot (ischemic stroke): 500-2000 mg of citicoline per day starting within 24 hours of stroke.

Memory disorders

In the hippocampi of rats with induced Alzheimer’s Disease, citicoline counteracts neuronal degeneration and reduces the number of apoptotic cells present.

Ischemic stroke

Citicoline is approved for treatment in cases of head trauma, stroke, and neurodegenerative disease in Kenya and the world at large. Citicoline improves the clinical outcome following an ischemic stroke, as evidenced by the reduction in size of lesions caused by ischemic strokes after supplementation. It has been claimed that citicoline reduces rates of death and disability following an ischemic stroke. However, the largest trial to date, a randomised, placebo-controlled, sequential trial in patients with moderate-to-severe acute ischaemic stroke in Europe, enrolling 2298 patients, found no benefit of administering citicoline on survival or recovery from stroke.[14]

It should be noted that citicoline is the only substance that ever showed any significant neuroprotective effect at least in patients with less severe stroke events.

Vision

Citicoline improves visual function in patients with glaucoma and amblyopia.

Satiety

Cocaine dependence is associated with depleted dopamine levels in the central nervous system. In cocaine-dependent individuals citicoline increases brain dopamine levels and reduces cravings.[19] In the general population citicoline increases brain responses to food stimuli, specifically in the amygdala, insula, and lateral orbitofrontal cortex, which correlate with decreased appetite.

Side Effects

Citicoline is POSSIBLY SAFE when taken by mouth short-term (up to 90 days). The safety of long-term use is not known. Most people who take citicoline don’t experience problematic side effects. But some people can have side effects such as trouble sleeping (insomnia), headache, diarrhea, low or high blood pressure, nausea, blurred vision, chest pains, and others.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking citicoline if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

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