Flupentixol has also been given as the hydrochloride, by mouth, for the treatment of mild to moderate depression, with or without anxiety. The usual initial dose, expressed in terms of the equivalent amount of flupentixol, is 1 mg (0.5 mg in the elderly) daily, increased after 1 week to 2 mg (1 mg in the elderly) and then to a maximum of 3 mg (2 mg in the elderly) daily. Doses above 2 mg (1 mg in the elderly) should be given in 2 divided doses. The last dose of the day should be given no later than 4 p.m. and if no effect has been noted within 1 week of reaching the maximum dose, treatment should be withdrawn.
In the treatment of depression in Kenya melitracen is given by mouth as the hydrochloride although doses are expressed in terms of the base; melitracen hydrochloride 28.1 mg is equivalent to about 25 mg of melitracen. The recommended initial dose is the equivalent of 25 mg two or three times daily gradually increased to a total of 225 mg daily if necessary. Elderly patients should generally be given reduced doses of 25 or 30 mg daily initially. Melitracen should be withdrawn gradually to reduce the risk of withdrawal symptoms.