IMURAN 50MG (AZATHIOPRINE 50MG) is an immunosuppressant drug used mostly in transplant surguries to prevent organ rejection. You can buy it online in Kenya.

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Uses and Administration of Azathioprine in Kenya

Azathioprine is an immunosuppressive antimetabolite with similar actions to those of mercaptopurine, to which it is converted in the body. Its effects may not be seen for several weeks after a dose. It is given by mouth, but in Kenyan patients in whom oral use is not feasible it may be given by slow intravenous injection or by infusion as azathioprine sodium.

In Kenya, Azathioprine is mainly used as an immunosuppressant for the prevention of rejection in organ and tissue transplantation. The dose for this purpose varies from 1 to 5 mg/kg daily and depends partly on the regimen employed; the higher doses are used initially, adjusted according to clinical response and haematological tolerance.

Azathioprine is also used in auto-immune diseases in Kenya or conditions that are considered to have an auto-immune component. The usual dose of azathioprine in these conditions is in the range of 1 to 3 mg/kg daily by mouth.

Use of azathioprine with a corticosteroid may have a corticosteroid-sparing effect.

Blood counts should be carried out regularly during treatment and azathioprine withdrawn or the dosage reduced at the first indication of bone-marrow depression.

Adverse Effects of Cyclosporin

Dose-related bone-marrow depression may be manifested as leucopenia or, less often, thrombocytopenia or anaemia, and may occasionally be delayed. Macrocytic, including megaloblastic, anaemia has occurred. Azathioprine has also been associated with the development of liver damage; it has been suggested that cholestatic symptoms may be due to the mercaptopurine moiety. Rarely, delayed and potentially fatal veno-occlusive liver disease has occurred in Kenya.

Other side-effects associated with azathioprine include gastrointestinal disturbances, reversible alopecia, and symptoms including rashes, muscle and joint pains, fever, rigors, pneumonitis, pancreatitis, tachycardia, renal dysfunction, and hypotension, some or all of which may represent hypersensitivity reactions.

Solutions for injection are irritant.

Breastfeeding and Azathioprine in Kenya.

Low concentrations of mercaptopurine have been found in human colostrum and breast milk of patients taking azathioprine. Breast feeding by these patients has not been recommended because of the potential risk of immunosuppression in the infant. However, there are reports of 3 breast-fed infants, whose mothers had been taking doses of 75 or 100 mg of azathioprine daily, in whom no evidence of immunosuppression was found. All 3 had normal blood counts, no increase in infections, and above average growth rate. In one case, the levels of mercaptopurine were determined at 2 days and after 2 weeks of breast feeding, and in the other 2 cases, no levels were determined. Therefore, to use Azathioprine on a breastfeeding mother in Kenya; The risk and benefits must be weighed and the condition of the infant monitored closely after every breastfeeding session.

Us of Azathioprine in Pregnancy.

Despite reports of chromosomal aberrations or fetal growth retardation in the offspring of mothers who received azathioprine during pregnancy, there seems to be little evidence that azathioprine is teratogenic in humans. Given the nature of the severe chronic conditions for which azathioprine is generally used for in Kenya, discontinuing therapy in patients who become pregnant may not be necessary or desirable, but it seems prudent to avoid its use where possible during pregnancy. Leucopenia has been reported in neonates whose mothers received azathioprine during pregnancy.

Interactions of Azathioprine and other drugs

The effects of azathioprine are enhanced by allopurinol and the dose of azathioprine should be reduced to one-third to one-quarter of the usual dose when allopurinol is given.

Single-ingredient Preparations of Azathioprine

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Kenya – Azoran, Imuran

Arg.: Imuran; Austral.: Azahexal; Azamun; Imuran; Thioprine; Austria: Azarek; Imurek; Belg.: Imuran; Braz.: Imunen; Imuran; Canad.: Imuran; Chile: Azafalk; Imuran; Denm.: Imurel; Fin.: Azamun; Imuprin; Imurel; Fr.: Imurel; Ger.: Azafalk; Azamedac; Azathiodura; Colinsan; Imurek; Zytrim; Gr.: Imuran; Hong Kong: Azamun; Imuran; Hung.: Imuran; India: Azoran; Imuran; Transimune; Irl.: Azopine¤; Imuger; Imuran; Israel: Azopi; Imuran; Ital.: Imuran¤; Malaysia: Imuran; Mex.: Aseroprim¤; Azatrilem; Imuran; Satedon¤; Tiosalprin¤; Neth.: Imuran; Norw.: Imurel; NZ: Azamun; Imuran; Thioprine; Port.: Imuran; S.Afr.: Azapress; Imuran; Singapore: Imuran; Spain: Imurel; Swed.: Imurel; Switz.: Imurek; Thai.: Imuran; UK: Azamune¤; Berkaprine¤; Immunoprin; Imuran; Oprisine¤; USA: Azasan; Imuran;


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